{Reference Type}: Journal Article {Title}: Lactiplantibacillus plantarum OL5 biosurfactants as alternative to chemical surfactants for application in eco-friendly cosmetics and skincare products. {Author}: Ben Ammar A;Ben Ali M;Cherif B;Gargouri B;Tahri Y;Rouis S;Ghribi D; {Journal}: Bioprocess Biosyst Eng {Volume}: 47 {Issue}: 7 {Year}: 2024 Jul 14 {Factor}: 3.434 {DOI}: 10.1007/s00449-024-03022-3 {Abstract}: Cosmetics have been extremely popular throughout history and continue to be so today. Cosmetic and personal care products, including toothpaste, shampoo, lotions, and makeup, are typically made with petroleum-based surfactants. Currently, there is an increasing demand to enhance the sustainability of surface-active compounds in dermal formulations. Biosurfactants, derived from living cells, are considered more environmentally friendly than synthetic surfactants. Thus, the use of biosurfactants is a promising strategy for formulating more environmentally friendly and sustainable dermal products. Biosurfactants have the potential to replace chemical surface-active agents in the cosmetic sector due to their multifunctional qualities, such as foaming, emulsifying, and skin-moisturizing activities.In this study, two glycolipopeptide biosurfactants derived from Lactiplantibacillus plantarum OL5 were used as stabilizing factors in oil-in-water emulsions in the presence of coconut oils. Both biosurfactants increased emulsion stability, particularly in the 1:3 ratio, dispersion, and droplet size. Moreover, the cytotoxicity of the two Lactiplantibacillus plantarum biosurfactants was assessed on B lymphocytes and MCF-7 cells. Overall, the results gathered herein are very promising for the development of new green cosmetic formulations.