{Reference Type}: Case Reports
{Title}: Osteoblastoma of the thumb with a novel PRSS44::ALK fusion and literature review of osteoblastoma of hands and feet bones.
{Author}: Brandea AI;Afkhami M;Klein MJ;Bell D;
{Journal}: Genes Chromosomes Cancer
{Volume}: 63
{Issue}: 5
{Year}: 2024 05
{Factor}: 4.263
{DOI}: 10.1002/gcc.23241
{Abstract}: Osteoblastomas (OBs) are benign neoplasms constituting approximately 1% of primary bone tumors with a predilection for the spine and sacrum. We describe an OB of the proximal phalanx of the left thumb in a 38-year-old female. MRI of left hand demonstrated a 29-mm mildly expansile enhancing lesion involving the entire proximal phalanx of the first digit. Histology displayed a bone-forming tumor consisting of trabeculae of remodeled woven bone framed by plump osteoblasts in a vascularized background. Next-generation sequencing analysis identified a PRSS44::ALK fusion gene.