{Reference Type}: Journal Article
{Title}: A Human-Scale Clinically Ready Electromagnetic Navigation System for Magnetically Responsive Biomaterials and Medical Devices.
{Author}: Gervasoni S;Pedrini N;Rifai T;Fischer C;Landers FC;Mattmann M;Dreyfus R;Viviani S;Veciana A;Masina E;Aktas B;Puigmartí-Luis J;Chautems C;Pané S;Boehler Q;Gruber P;Nelson BJ;
{Journal}: Adv Mater
{Volume}: 36
{Issue}: 31
{Year}: 2024 Aug 11
{Factor}: 32.086
{DOI}: 10.1002/adma.202310701
{Abstract}: Magnetic navigation systems are used to precisely manipulate magnetically responsive materials enabling the realization of new minimally invasive procedures using magnetic medical devices. Their widespread applicability has been constrained by high infrastructure demands and costs. The study reports on a portable electromagnetic navigation system, the Navion, which is capable of generating a large magnetic field over a large workspace. The system is easy to install in hospital operating rooms and transportable through health care facilities, aiding in the widespread adoption of magnetically responsive medical devices. First, the design and implementation approach for the system are introduced and its performance is characterized. Next, in vitro navigation of different microrobot structures is demonstrated using magnetic field gradients and rotating magnetic fields. Spherical permanent magnets, electroplated cylindrical microrobots, microparticle swarms, and magnetic composite bacteria-inspired helical structures are investigated. The navigation of magnetic catheters is also demonstrated in two challenging endovascular tasks: 1) an angiography procedure and 2) deep navigation within the circle of Willis. Catheter navigation is demonstrated in a porcine model in vivo to perform an angiography under magnetic guidance.