{Reference Type}: Journal Article
{Title}: Cancer Precursor Syndromes and Their Detection in the Head and Neck.
{Author}: Villa A;William WN;Hanna GJ;
{Journal}: Hematol Oncol Clin North Am
{Volume}: 38
{Issue}: 4
{Year}: 2024 Aug 4
{Factor}: 2.861
{DOI}: 10.1016/j.hoc.2024.04.001
{Abstract}: This article explores the multifaceted landscape of oral cancer precursor syndromes. Hereditary disorders like dyskeratosis congenita and Fanconi anemia increase the risk of malignancy. Oral potentially malignant disorders, notably leukoplakia, are discussed as precursors influenced by genetic and immunologic facets. Molecular insights delve into genetic mutations, allelic imbalances, and immune modulation as key players in precancerous progression, suggesting potential therapeutic targets. The article navigates the controversial terrain of management strategies of leukoplakia, encompassing surgical resection, chemoprevention, and immune modulation, while emphasizing the ongoing challenges in developing effective, evidence-based preventive approaches.