{Reference Type}: Journal Article
{Title}: Wearable electrocardiogram devices in patients with congenital long QT syndrome: The SMART-QT study.
{Author}: Delinière A;Bessière F;Placide L;Pasquié JL;Haddad C;Tirel S;Mokhtar H;Morel E;Gardey K;Dulac A;Ditac G;Sacher F;Denjoy I;Chevalier P;
{Journal}: Arch Cardiovasc Dis
{Volume}: 117
{Issue}: 5
{Year}: 2024 May 24
{Factor}: 3.196
{DOI}: 10.1016/j.acvd.2024.02.010
{Abstract}: <B>BACKGROUND: </B>In patients with congenital long QT syndrome (LQTS), the risk of ventricular arrhythmia is correlated with the duration of the corrected QT interval and the changes in the ST-T wave pattern on the 12-lead surface electrocardiogram (12L-ECG). Remote monitoring of these variables could be useful.<BR><B>OBJECTIVE: </B>To evaluate the abilities of two wearable electrocardiogram devices (Apple Watch and KardiaMobile 6L) to provide reliable electrocardiograms in terms of corrected QT interval and ST-T wave patterns in patients with LQTS.<BR><B>METHODS: </B>In a prospective multicentre study (ClinicalTrials.gov identifier: NCT04728100), a 12L-ECG, a 6-lead KardiaMobile 6L electrocardiogram and two single-lead Apple Watch electrocardiograms were recorded in patients with LQTS. The corrected QT interval and ST-T wave patterns were evaluated manually.<BR><B>RESULTS: </B>Overall, 98 patients with LQTS were included; 12.2% were children and 92.8% had a pathogenic variant in an LQTS gene. The main genotypes were LQTS type 1 (40.8%), LQTS type 2 (36.7%) and LQTS type 3 (7.1%); rarer genotypes were also represented. When comparing the ST-T wave patterns obtained with the 12L-ECG, the level of agreement was moderate with the Apple Watch (k=0.593) and substantial with the KardiaMobile 6L (k=0.651). Regarding the corrected QT interval, the correlation with 12L-ECG was strong for the Apple Watch (r=0.703 in lead II) and moderate for the KardiaMobile 6L (r=0.593). There was a slight overestimation of corrected QT interval with the Apple Watch and a subtle underestimation with the KardiaMobile 6L.<BR><B>CONCLUSIONS: </B>In patients with LQTS, the corrected QT interval and ST-T wave patterns obtained with the Apple Watch and the KardiaMobile 6L correlated with the 12L-ECG. Although wearable electrocardiogram devices cannot replace the 12L-ECG for the follow-up of these patients, they could be interesting additional monitoring tools.