{Reference Type}: Journal Article
{Title}: Superacute onset of Guillain-Barré syndrome after elective spinal surgery: A case report and literature review.
{Author}: Zhang X;Yu D;
{Journal}: Medicine (Baltimore)
{Volume}: 103
{Issue}: 18
{Year}: 2024 May 3
{Factor}: 1.817
{DOI}: 10.1097/MD.0000000000037925
{Abstract}: <B>BACKGROUND: </B>Guillain-Barré syndrome (GBS) epitomizes an acute peripheral neuropathy hallmarked by an autoimmune retort directed at the myelin sheath enwrapping peripheral nerves. While it is widely acknowledged that a majority of GBS patients boast a history of antecedent infections, the documentation of postoperative GBS occurrences is progressively mounting. Drawing upon an exhaustive compendium of recent case reports, the disease's inception spans a gamut from within 1 hour to 1.2 years.<BR><B>METHODS: </B>At this juncture, we proffer a singular case: an instance involving a 51-year-old gentleman who underwent lumbar spine surgery, only to encounter immediate debilitation of limb and respiratory musculature.<BR><B>METHODS: </B>Post elimination of variables linked to anesthetic agents, encephalon, and spinal cord pathologies, a potent suspicion of superacute GBS onset emerged.<BR><B>METHODS: </B>Subsequent to immunoglobulin therapy, plasmapheresis, and adjunctive support, the patient's ultimate demise became manifest.<BR><B>RESULTS: </B>No progress was found to date.<BR><B>CONCLUSIONS: </B>Given GBS's potential to instigate paralysis, respiratory collapse, and autonomic nervous system aberrations, alongside other pernicious sequelae, coupled with the exceptional rarity of the temporal onset in this particular instance, it undeniably proffers an imposing conundrum for anesthetists in the realm of differential diagnosis and therapeutic conduct. During the postoperative convalescence phase under anesthesia, should the patient evince deviant limb musculature vigor and compromised respiratory sinews, the prospect of GBS must not be consigned to oblivion. Precision in diagnosis conjoined with apt therapeutic measures could well be the harbinger of a divergent denouement for the afflicted patient.