{Reference Type}: Journal Article
{Title}: Present status of scheduled vaccinations and vaccination-related bleeding in Chinese children with haemophilia.
{Author}: Li Z;Zhou Y;Li K;Zhao Y;Song Y;Xiao J;
{Journal}: J Paediatr Child Health
{Volume}: 60
{Issue}: 6
{Year}: 2024 Jun 3
{Factor}: 1.929
{DOI}: 10.1111/jpc.16554
{Abstract}: <B>OBJECTIVE: </B>Many countries have detailed recommendations for haemophilia patients to reduce the risk of vaccination-related bleeding. However, data from developing countries are lacking. We investigated scheduled vaccinations and vaccination-related bleeding complications in Chinese children with haemophilia and analysed issues related to vaccinations.<BR><B>METHODS: </B>Children with haemophilia in the PUMCH Haemophilia Treatment Centre were contacted via telephone. We distributed a vaccination questionnaire to their parents. The severity of haemophilia, coagulation factor infusions before vaccination, injection mode, and vaccination-related complications were analysed.<BR><B>RESULTS: </B>A total of 440 valid questionnaires were received from 27 of 34 provinces in China. 31.3% (138/440) of the children with haemophilia did not receive all of their vaccinations. Among the children who received vaccinations, 48.1% (197/409) experienced bleeding complications. In patients with severe haemophilia, those on regular prophylaxis had a lower incidence of local hematoma compared to those on intermittent or no prophylaxis (14.3% vs. 26.5% vs. 39.7%, P < 0.05). The incidence of local hematomas was lower by subcutaneous (SQ) injections than by intramuscular injections (24.6% vs. 35.3%, P < 0.05).<BR><B>CONCLUSIONS: </B>The vaccination rate is quite insufficient in Chinese children with haemophilia. Missed vaccinations are related to vaccination-related bleeding complications. Prophylaxis before vaccination and SQ injections would help reduce bleeding complications.