{Reference Type}: Journal Article
{Title}: Inclusion body myositis, viral infections, and TDP-43: a narrative review.
{Author}: Văcăraş V;Vulturar R;Chiş A;Damian L;
{Journal}: Clin Exp Med
{Volume}: 24
{Issue}: 1
{Year}: 2024 May 2
{Factor}: 5.057
{DOI}: 10.1007/s10238-024-01353-9
{Abstract}: The ubiquitous RNA-processing molecule TDP-43 is involved in neuromuscular diseases such as inclusion body myositis, a late-onset acquired inflammatory myopathy. TDP-43 solubility and function are disrupted in certain viral infections. Certain viruses, high viremia, co-infections, reactivation of latent viruses, and post-acute expansion of cytotoxic T cells may all contribute to inclusion body myositis, mainly in an age-shaped immune landscape. The virally induced senescent, interferon gamma-producing cytotoxic CD8+ T cells with increased inflammatory, and cytotoxic features are involved in the occurrence of inclusion body myositis in most such cases, in a genetically predisposed host. We discuss the putative mechanisms linking inclusion body myositis, TDP-43, and viral infections untangling the links between viruses, interferon, and neuromuscular degeneration could shed a light on the pathogenesis of the inclusion body myositis and other TDP-43-related neuromuscular diseases, with possible therapeutic implications.