{Reference Type}: Journal Article
{Title}: A watch, wait, and rescan approach for incidental benign-appearing notochordal lesions of the skull base.
{Author}: Usher IE;Drosos E;Morsy A;Wadeson A;Laitt R;Abdulla S;Madhavan A;Halliday J;Rutherford S;King AT;Pathmanaban ON;
{Journal}: Neurosurg Focus
{Volume}: 56
{Issue}: 5
{Year}: 2024 05
{Factor}: 4.332
{DOI}: 10.3171/2024.2.FOCUS23912
{Abstract}: The aim of this study was to describe the natural history of incidental benign-appearing notochordal lesions of the skull base with specific attention to features that can make differentiation from low-grade chordoma more difficult, namely contrast uptake and bone erosion.<BR>In this retrospective case series, the authors describe the clinical outcomes of 58 patients with incidental benign-appearing notochordal lesions of the clivus, including those with minor radiological features of bone erosion or contrast uptake.<BR>All lesions remained stable during a median follow-up of almost 3 years. Thirty-seven (64%) patients underwent contrast-enhanced MRI; lesions in 14 (38%) of these patients exhibited minimal contrast enhancement. Twenty-seven (47%) patients underwent CT; lesions in 6 (22%) of these patients exhibited minimal bone erosion.<BR>These data make the case for monitoring selected cases of benign-appearing notochordal lesions of the clivus in the first instance even when there is minor contrast uptake or minimal bone erosion.