{Reference Type}: Journal Article
{Title}: Sucrose-Powered Liposome Nanosensors for Urinary Glucometer-Based Monitoring of Cancer.
{Author}: Zhou D;Zhang Z;Pan L;Wang Y;Yang J;Gao Y;Song Y;
{Journal}: Angew Chem Int Ed Engl
{Volume}: 63
{Issue}: 28
{Year}: 2024 07 8
{Factor}: 16.823
{DOI}: 10.1002/anie.202404493
{Abstract}: Timely detection of early-stage cancer holds immense potential in enhancing prognostic outcomes. There is an increasing desire for versatile tools to enable simple, sensitive, and cost-effective cancer detection. By exploiting the extraintestinal metabolic inertness and efficiency renal clearance of sucrose, we designed a liposome nanosensor using sucrose as a messenger to convert tumor-specific esterase activity into glucose meter readout, enabling economical and sensitive urinalysis for cancer detection in point-of-care testing (POCT). Our results demonstrate that the nanosensors exhibited significant signal differences between tumor-bearing and healthy mice in both orthotopic and metastatic tumor models. Additionally, efficient elimination of the nanosensors through the hepatobiliary pathway was observed with no significant toxicity. Such a non-invasive diagnostic modality significantly assists in personalized pharmacological treatment and follow-up efficacy assessment. We envision that this modular liposome nanosensor platform might be applied for economically detecting diverse diseases via a simple urinary test.