{Reference Type}: Journal Article
{Title}: Studies on cationic ocular emulsions containing bipartitioned oil droplets to codeliver cyclosporin A and etodolac.
{Author}: Ruhina Rahman SN;Goswami A;Jala A;Venuganti A;Deka A;Borkar RM;Singh V;Das D;Shunmugaperumal T;
{Journal}: Nanomedicine (Lond)
{Volume}: 19
{Issue}: 12
{Year}: 2024 Apr 30
{Factor}: 6.096
{DOI}: 10.2217/nnm-2023-0364
{Abstract}: Background: To prepare ocular emulsions containing bipartitioned oil droplets to entrap cyclosporin A (0.05% w/w) and etodolac (0.2% w/w) by using castor, olive and silicon oils. Methods: The physicochemical characterizations of prepared emulsions were performed. The drug's biodistribution profiles and pharmacokinetic parameters from emulsions were checked using the ultraperformance liquid chromatography-tandem mass spectrometry method in the ocular tissues of the healthy rabbit eye model. Results: The emulsions displayed 365.13 ± 7.21 nm size and 26.45 ± 2.09 mV zeta potential. The ferrying of two drugs after releasing from emulsions occurred across corneal/conjunctival tissues to enter the vitreous and sclera following a single drop administration into the rabbit's eyes. Conclusion: The dual drug-loaded emulsions were more likely to produce synergistic anti-inflammatory activity for managing moderate-to-severe dry eye disease.<BR>[Box: see text].