{Reference Type}: Journal Article
{Title}: Relationship of interleukin-16 with different phenogroups in acute heart failure with preserved ejection fraction.
{Author}: Tamaki S;Sotomi Y;Nagai Y;Shutta R;Masuda D;Makino N;Yamashita S;Seo M;Yamada T;Nakagawa A;Yasumura Y;Nakagawa Y;Yano M;Hayashi T;Hikoso S;Nakatani D;Ohtani T;Sakata Y; ;
{Journal}: ESC Heart Fail
{Volume}: 11
{Issue}: 4
{Year}: 2024 Aug 30
{Factor}: 3.612
{DOI}: 10.1002/ehf2.14808
{Abstract}: <B>OBJECTIVE: </B>Interleukin-16 (IL-16) has been reported to mediate left ventricular myocardial fibrosis and stiffening in patients with heart failure with preserved ejection fraction (HFpEF). We sought to elucidate whether IL-16 has a distinct impact on pathophysiology and prognosis across different subphenotypes of acute HFpEF.<BR><B>RESULTS: </B>We analysed 211 patients enrolled in a prospective multicentre registry of acute decompensated HFpEF for whom serum IL-16 levels after stabilization were available (53% female, median age 81 [interquartile range 75-85] years). We divided this sub-cohort into four phenogroups using our established clustering algorithm. The study endpoint was all-cause death. Patients were subclassified into phenogroup 1 ('rhythm trouble' [n = 69]), phenogroup 2 ('ventricular-arterial uncoupling' [n = 49]), phenogroup 3 ('low output and systemic congestion' [n = 41]), and phenogroup 4 ('systemic failure' [n = 52]). After a median follow-up of 640 days, 38 patients had died. Among the four phenogroups, phenogroup 2 had the highest IL-16 level. The IL-16 level showed significant associations with indices of cardiac hypertrophy, diastolic dysfunction, and congestion only in phenogroup 2. Furthermore, the IL-16 level had a significant predictive value for all-cause death only in phenogroup 2 (C-statistic 0.750, 95% confidence interval 0.606-0.863, P = 0.017), while there was no association between the IL-16 level and the endpoint in the other phenogroups.<BR><B>CONCLUSIONS: </B>Our results indicated that the serum IL-16 level had a significant association with indices that reflect the pathophysiology and prognosis of HFpEF in a specific phenogroup in acute HFpEF.