{Reference Type}: Journal Article
{Title}: Technological advancements in functional interpretation of genome-wide association studies (GWAS) findings: bridging the gap to clinical translation.
{Author}: Aherrahrou R;Kaikkonen MU;
{Journal}: FEBS Lett
{Volume}: 0
{Issue}: 0
{Year}: 2024 Apr 29
{Factor}: 3.864
{DOI}: 10.1002/1873-3468.14884
{Abstract}: Genome-wide association studies (GWAS) significantly advanced our understanding of the genetic underpinnings of diseases. However, challenges persist, particularly in interpreting non-coding variants in linkage disequilibrium that affect genes in disease-relevant cells. Addressing key obstacles-identifying causal variants, uncovering target genes, and understanding their network impact-is crucial. This graphical review navigates advanced techniques to fully leverage GWAS for future therapeutic breakthroughs.