{Reference Type}: Case Reports {Title}: From benign to malignant: unveiling invasive squamous cell carcinoma following resection of perianal condyloma acuminatum: a case report. {Author}: Ylli K;ElJack W;Spillane C;Cotter M;Killeen S; {Journal}: J Surg Case Rep {Volume}: 2024 {Issue}: 4 {Year}: 2024 Apr 暂无{DOI}: 10.1093/jscr/rjae266 {Abstract}: This case illustrates the surgical management of a perianal mass, initially misdiagnosed as condyloma acuminatum in a male patient in his late 50s, later identified as invasive squamous cell carcinoma following excision. Despite extensive preoperative evaluation, the lesion's malignancy was confirmed through histopathology. The significant, fungating mass required a multidisciplinary approach, culminating in a pT3 staging and additional wide excision with inferior gluteal artery perforator flap reconstruction. This case underscores the critical importance of surgical diligence and adaptability, highlighting the role of comprehensive surgery in both diagnosis and treatment of complex perianal malignancies, and reaffirms the value of a multidisciplinary team in achieving favourable outcomes.