{Reference Type}: Journal Article
{Title}: Vitamin D receptor gene polymorphisms role in COVID-19 severity: Results of a Mexican patients' cohort.
{Author}: Ochoa-Ramírez LA;Corona-Angulo AL;Ríos-Burgueño ER;Sánchez-Zazueta JG;Becerra-Loaiza DS;Velarde-Félix JS;
{Journal}: Int J Immunogenet
{Volume}: 51
{Issue}: 4
{Year}: 2024 Aug 28
{Factor}: 2.385
{DOI}: 10.1111/iji.12674
{Abstract}: Vitamin D status has been involved with coronavirus disease 19 (COVID-19) severity. This may be mediated by vitamin D metabolism regulatory genes. Of interest is the vitamin D receptor (VDR) gene, which has been previously associated with other inflammatory and respiratory diseases. In order to investigate the role of VDR gene polymorphisms in COVID-19 severity and outcome, a total of 292 COVID-19 patients were classified according to severity in moderate (n = 56), severe (n = 89) and critical (n = 147) and, according to outcome in survivor (n = 163) and deceased (n = 129), and analysed for FokI and TaqI VDR gene polymorphisms by polymerase chain reaction-based restriction enzyme digestion. The FokI and TaqI single nucleotide polymorphisms (SNPs) were not associated with COVID-19 severity or mortality individually but when analysed by haplotype, TC was associated with an increased risk of presenting critical COVID-19. Additionally, FokI CT genotype was more frequent in COVID-19 patients with hypertension, and T allele carriers presented higher aspartate aminotransferase levels. Our results suggest a relationship between VDR FokI and TaqI SNPs and COVID-19 severity in Mexican population. Although there are some previous reports of VDR polymorphisms in COVID-19, this represents the first report in Latin American population. Further studies on other populations are encouraged.