{Reference Type}: Journal Article
{Title}: Association of the IFNG +874T/A Polymorphism with Symptomatic COVID-19 Susceptibility.
{Author}: Sarges KML;Póvoa da Costa F;Santos EFD;Cantanhede MHD;da Silva R;Veríssimo AOL;Viana MNDSA;Rodrigues FBB;Leite MM;Torres MKDS;Bentes da Silva C;Brito MTFM;Silva ALSD;Henriques DF;Vallinoto IMVC;Viana GMR;Queiroz MAF;Vallinoto ACR;Santos EJMD;
{Journal}: Viruses
{Volume}: 16
{Issue}: 4
{Year}: 2024 04 22
{Factor}: 5.818
{DOI}: 10.3390/v16040650
{Abstract}: Tumor necrosis factor (TNF) and interferon-gamma (IFNγ) are important inflammatory mediators in the development of cytokine storm syndrome (CSS). Single nucleotide polymorphisms (SNPs) regulate the expression of these cytokines, making host genetics a key factor in the prognosis of COVID-19. In this study, we investigated the associations of the TNF -308G/A and IFNG +874T/A polymorphisms with COVID-19. We analyzed the frequencies of the two polymorphisms in the control groups (CG: TNF -308G/A, n = 497; IFNG +874T/A, n = 397), a group of patients with COVID-19 (CoV, n = 222) and among the subgroups of patients with nonsevere (n = 150) and severe (n = 72) COVID-19. We found no significant difference between the genotypic and allelic frequencies of TNF -308G/A in the groups analyzed; however, both the frequencies of the high expression genotype (TT) (CoV: 13.51% vs. CG: 6.30%; p = 0.003) and the *T allele (CoV: 33.56% vs. CG: 24. 81%; p = 0.001) of the IFNG +874T/A polymorphism were higher in the COVID-19 group than in the control group, with no differences between the subgroups of patients with nonsevere and severe COVID-19. The *T allele of IFNG +874T/A (rs2430561) is associated with susceptibility to symptomatic COVID-19. These SNPs provided valuables clues about the potential mechanism involved in the susceptibility to developing symptomatic COVID-19.