{Reference Type}: Journal Article
{Title}: Advancing Postoperative Pain Management in Oral Cancer Patients: A Systematic Review.
{Author}: Inchingolo AM;Dipalma G;Inchingolo AD;Palumbo I;Guglielmo M;Morolla R;Mancini A;Inchingolo F;
{Journal}: Pharmaceuticals (Basel)
{Volume}: 17
{Issue}: 4
{Year}: 2024 Apr 22
{Factor}: 5.215
{DOI}: 10.3390/ph17040542
{Abstract}: The goal of this review is to shed light on the management of orofacial discomfort after a cancer diagnosis in the head and neck region. A search was conducted on PubMed, Scopus, and Web of Science to identify studies on postoperative pain control in oral cancer. The review included open-access research, investigations into pain management, randomized clinical trials, retrospective studies, case-control studies, prospective studies, English-written studies, and full-text publications. Exclusion criteria included animal studies; in vitro studies; off-topic studies; reviews, case reports, letters, or comments; and non-English language. Three reviewers independently accessed databases and assigned a quality rating to the chosen articles. The review explores postoperative pain management in oral cancer patients; highlighting persistent opioid use; the efficacy of adjuvant drugs, such as gabapentin; and a multimodal approach. It emphasizes the need for personalized pain management, recognizing individual pain perception and tailoring interventions. Integrating pharmacological and non-pharmacological strategies is crucial for comprehensive pain management. The review also serves as a guide for future research, emphasizing the need for standardized methodologies and diverse participant populations.