{Reference Type}: Journal Article
{Title}: Technological Development and Advances for Constructing and Analyzing Plant Pangenomes.
{Author}: Hu H;Li R;Zhao J;Batley J;Edwards D;
{Journal}: Genome Biol Evol
{Volume}: 16
{Issue}: 4
{Year}: 2024 04 2
{Factor}: 4.065
{DOI}: 10.1093/gbe/evae081
{Abstract}: A pangenome captures the genomic diversity for a species, derived from a collection of genetic sequences of diverse populations. Advances in sequencing technologies have given rise to three primary methods for pangenome construction and analysis: de novo assembly and comparison, reference genome-based iterative assembly, and graph-based pangenome construction. Each method presents advantages and challenges in processing varying amounts and structures of DNA sequencing data. With the emergence of high-quality genome assemblies and advanced bioinformatic tools, the graph-based pangenome is emerging as an advanced reference for exploring the biological and functional implications of genetic variations.