{Reference Type}: Case Reports {Title}: Detection of OXA-181 Carbapenemase in Shigella flexneri. {Author}: Dhabaan G;Jamal H;Ouellette D;Alexander S;Arane K;Campigotto A;Tadros M;Piché-Renaud PP; {Journal}: Emerg Infect Dis {Volume}: 30 {Issue}: 5 {Year}: 2024 May {Factor}: 16.126 {DOI}: 10.3201/eid3005.231558 {Abstract}: We report the detection of OXA-181 carbapenemase in an azithromycin-resistant Shigella spp. bacteria in an immunocompromised patient. The emergence of OXA-181 in Shigella spp. bacteria raises concerns about the global dissemination of carbapenem resistance in Enterobacterales and its implications for the treatment of infections caused by Shigella bacteria.