{Reference Type}: Journal Article
{Title}: Effect of 1,4-Dioxane Solvent on β-Glucuronidation Using Methyl 1,2,3,4-Tetra-O-acetyl-β-D-glucuronate as the Glycosyl Donor.
{Author}: Kajimoto T;Du T;Kaneko K;Matsushima Y;Miura T;
{Journal}: Chem Pharm Bull (Tokyo)
{Volume}: 72
{Issue}: 4
{Year}: 2024
{Factor}: 1.903
{DOI}: 10.1248/cpb.c24-00068
{Abstract}: A facile and selective β-D-glucuronidation of alcohols, such as (-)-menthol, cholestanol, (+)- and (-)-borneols, and 2-adamantanol, using commercially available methyl 1,2,3,4-tetra-O-acetyl-β-D-glucuronate as the glycosyl donor and trimethylsilyl bis(trifluoromethanesulfonyl)imide (Tf2NTMS) (0.5 equivalent) as the activator in 1,4-dioxane at 60 °C gave products in moderate yields. The addition of MS4A increased the β : α ratios of D-glucuronides when cholestanol, (+)-borneol, and 2-adamantanol were used as the acceptor substrate.