{Reference Type}: Case Reports {Title}: Chronic spontaneous urticaria preceded by localized insulin reactions: case report. {Author}: Momin ZK;Chambliss JM; {Journal}: SAGE Open Med Case Rep {Volume}: 12 {Issue}: 0 {Year}: 2024 暂无{DOI}: 10.1177/2050313X241248383 {Abstract}: Chronic spontaneous urticaria presents with wheals and/or angioedema for >6 weeks without any specific triggers. The incidence of chronic spontaneous urticaria is increased in patients with comorbid autoimmune conditions. Here, we present a case of chronic spontaneous urticaria in a 9-year-old with type 1 diabetes and autoimmune thyroid disease who first presented with insulin pump site reactions concerning an insulin-related allergy. The patient was successfully treated with antihistamines and later immunosuppression with resumption of insulin pump therapy and remission of chronic spontaneous urticaria symptoms 18 months after onset.