{Reference Type}: Journal Article
{Title}: Surgical management of advanced sinonasal cancer: a 10-year mono-institutional experience.
{Author}: Sileo G;Arosio AD;Lambertoni A;Battaglia P;Bignami M;Cherubino M;Valdatta L;Antognoni P;Locatelli D;Castelnuovo P;Turri-Zanoni M;
{Journal}: Acta Otorhinolaryngol Ital
{Volume}: 44
{Issue}: 2
{Year}: 2024 Apr
{Factor}: 2.618
{DOI}: 10.14639/0392-100X-N2375
{Abstract}: <B>UNASSIGNED: </B>Endoscopic endonasal surgery is effective in the treatment of sinonasal cancers. However, in cases of well-differentiated locally advanced neoplasms as well as recurrences, the most appropriate treatment is debated. The purpose of this study is to report a mono-institutional experience on craniofacial surgery performed in a tertiary-care referral centre.<BR><B>UNASSIGNED: </B>This was a retrospective analysis of 90 patients treated with transcranial and/or transfacial resection for sinonasal cancer between 2010 and 2020. Outcome measures included overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS) and recurrence-free survival (RFS).<BR><B>UNASSIGNED: </B>The 5-year OS, DSS and DFS were 48.2%, 60.6% and 28.7%, respectively. Factors correlated with prognosis were pT-classification (p = 0.002), histotype (p = 0.012) and dural involvement (p = 0.004). Independent prognostic factors were orbital apex infiltration (p = 0.03), age (p = 0.002) and adjuvant therapy (p = 0.03).<BR><B>UNASSIGNED: </B>When endoscopic endonasal surgery is contraindicated and chemoradiotherapy is not appropriate, craniofacial and transfacial approaches still represent an option to consider, despite the non-negligible morbidity.