{Reference Type}: Journal Article
{Title}: The effects of hyperbaric oxygen therapy on neuroprotection and recovery after brain resuscitation.
{Author}: Li D;He X;Li Y;Wu S;Liu J;
{Journal}: Int J Neurosci
{Volume}: 0
{Issue}: 0
{Year}: 2024 May 13
{Factor}: 2.59
{DOI}: 10.1080/00207454.2024.2346172
{Abstract}: <B>UNASSIGNED: </B>Analyze the impact of hyperbaric oxygen therapy on neuroprotection and recovery post severe traumatic brain injury (sTBI) resuscitation.<BR><B>UNASSIGNED: </B>Retrospective analysis of clinical data from 83 sTBI patients admitted between January 2022 to January 2024. Patients were divided into control (n = 41) and observation (n = 42) groups based on treatment received. Control received standard therapy, while the observation group received hyperbaric oxygen therapy. Effects on clinical outcomes, neuroinjury markers (S100β, GFAP, UCH-L1, NSE), neurotrophic factors (NGF, BDNF), neurological function indicators (NIHSS, CSS), and adverse reactions were compared.<BR><B>UNASSIGNED: </B>The observation group showed a higher total effective rate (80.95%) compared to control (60.98%) (p < 0.05). Neuroinjury markers decreased post-treatment in both groups, with the observation group lower (p < 0.05). NGF and BDNF levels increased post-treatment in both groups, with the observation group higher (p < 0.05). NIHSS and CSS scores decreased post-treatment in both groups, with the observation group lower (p < 0.05). No significant difference in adverse reactions between groups (p > 0.05).<BR><B>UNASSIGNED: </B>Hyperbaric oxygen therapy effectively treats sTBI by improving brain resuscitation success, reducing neuroinjury factors, enhancing neurotrophic factors, and promoting neurological function recovery, without increasing adverse reaction risk.