{Reference Type}: Journal Article
{Title}: Minimum information and guidelines for reporting a multiplexed assay of variant effect.
{Author}: Claussnitzer M;Parikh VN;Wagner AH;Arbesfeld JA;Bult CJ;Firth HV;Muffley LA;Nguyen Ba AN;Riehle K;Roth FP;Tabet D;Bolognesi B;Glazer AM;Rubin AF;
{Journal}: Genome Biol
{Volume}: 25
{Issue}: 1
{Year}: 2024 04 19
暂无{DOI}: 10.1186/s13059-024-03223-9
{Abstract}: Multiplexed assays of variant effect (MAVEs) have emerged as a powerful approach for interrogating thousands of genetic variants in a single experiment. The flexibility and widespread adoption of these techniques across diverse disciplines have led to a heterogeneous mix of data formats and descriptions, which complicates the downstream use of the resulting datasets. To address these issues and promote reproducibility and reuse of MAVE data, we define a set of minimum information standards for MAVE data and metadata and outline a controlled vocabulary aligned with established biomedical ontologies for describing these experimental designs.