{Reference Type}: Journal Article
{Title}: Thiostrepton suppresses triple-negative breast cancer through downregulating c-FLIP/SMAD2/3 signaling pathway.
{Author}: Wang WD;Zeng CY;Shang Y;Ni J;Li GJ;Li LP;Xi SH;Chen SZ;
{Journal}: J Asian Nat Prod Res
{Volume}: 26
{Issue}: 8
{Year}: 2024 Aug 18
{Factor}: 1.61
{DOI}: 10.1080/10286020.2024.2343420
{Abstract}: Triple-negative breast cancer (TNBC) is an aggressive subtype with poor prognosis of breast cancer. Thiostrepton exerts anti-tumor activities against several cancers including TNBC. Herein we discussed the new molecular mechanisms of thiostrepton in TNBC. Thiostrepton inhibited MDA-MB-231 cell viability, accompanied by a decrease of c-FLIP and p-SMAD2/3. c-FLIP overexpression reduced the sensitivity of MDA-MB-231 cells to thiostrepton, while SMAD2/3 knockdown increased the sensitivity of MDA-MB-231 cells to thiostrepton. Moreover, c-FLIP overexpression significantly increased the expression and phosphorylation of SMAD2/3 proteins and vice versa. In conclusion, our study reveals c-FLIP/SMAD2/3 signaling pathway as a novel mechanism of antitumor activity of thiostrepton.