{Reference Type}: Review
{Title}: N6-adenosine methylation and the regulatory mechanism on LINE-1.
{Author}: Zhang A;Cen S;Li XY;
{Journal}: Yi Chuan
{Volume}: 46
{Issue}: 3
{Year}: 2024 Mar 20
暂无{DOI}: 10.16288/j.yczz.23-248
{Abstract}: Long interspersed elements-1(LINE-1) is the only autonomous transposon in human genome，and its retrotransposition results in change of cellular genome structure and function, leading occurrence of various severe diseases. As a central key intermediated component during life cycle of LINE-1 retrotransposition, the host modification of LINE-1 mRNA affects the LINE-1 transposition directly. N6-adenosine methylation(m6A), the most abundant epigenetic modification on eukaryotic RNA, is dynamically reversible. m6A modification is also found on LINE-1 mRNA, and it participants regulation of the whole LINE-1 replication cycle, with affecting LINE-1 retrotransposition as well as its adjacent genes expression, followed by influencing genomic stability, cellular self-renewal, and differentiation potential, which plays important roles in human development and diseases. In this review, we summarize the research progress in LINE-1 m6A modification, including its modification positions, patterns and related mechanisms, hoping to provide a new sight on the mechanism research and treatment of related diseases.<BR>长散布元件-1 (long interspersed elements-1，LINE-1)是现今在人类基因组中唯一具有自主转座能力的转座子，其转座会引起细胞基因组结构和功能的改变，是导致多种严重疾病的重要因素。在转座过程中，LINE-1 mRNA是转座中间体的核心，宿主细胞对其进行相关修饰直接影响转座。N6-腺苷甲基化修饰(m6A)是真核细胞RNA上最丰富且动态可逆的表观遗传修饰。目前发现m6A修饰也存在于LINE-1 mRNA上，参与LINE-1整个生命周期的调控，影响其转座和基因组中LINE-1相邻基因的表达，进而影响基因组稳定性、细胞自我更新与分化潜能，在人类发育和疾病中具有重要作用。本文介绍了LINE-1 m6A修饰的位置、功能以及相关机制，并总结了LINE-1的m6A修饰对其转座调控的研究进展，以期为相关疾病发生发展的机制研究和治疗提供新的思路。.