{Reference Type}: Journal Article
{Title}: Consumption of sucrose in maternal and postnatal stages leads to kidney affectation in adult male rats.
{Author}: Verónica VO;Leticia NT;Saret DS;Dora Luz CQ;Estela CR;Margarita MG;Arturo OS;Francisco C;Jorge RA;
{Journal}: Physiol Behav
{Volume}: 283
{Issue}: 0
{Year}: 2024 Sep 1
{Factor}: 3.742
{DOI}: 10.1016/j.physbeh.2024.114551
{Abstract}: High sugar-sweetened beverage intake has been related to human kidney disease and metabolic alterations. We determine the impact of high sucrose intake from pregnancy until early postnatal days and post-weaning on kidneys from adult male offspring rats. Wistar female rats were mated and assigned into two groups: one control drinking tap water (CM) and another drinking 5 % sucrose diluted in water (SM). Two offspring per mother were randomly allocated into two experimental groups at weaning. One had free access to simple water (CO) and the other to 5 % sucrose (SO) for 14 weeks. After treatment, levels of relative aquaporin-2 (AQP2), glomerulosclerosis index (GI), collecting tube area, perirenal fat, blood creatinine, and blood ureic nitrogen concentration (BUN) were determined. Two-way ANOVA followed by Bonferroni post-hoc test was used, considering P ≤ 0.05 as a significant statistical difference. Sucrose consumption during gestation/lactation and interaction increased AQP2 expression in the renal cortex and BUN concentration. In contrast, gestation/lactation consumption increased collecting tube area, post-weaning consumption favored perirenal fat, and finally, gestation/lactation, post-weaning, and the interaction caused glomerulosclerosis. Our results suggest that the consumption of sucrose water during gestation/lactation or post-weaning or combination triggers pathological changes in the kidneys of adult rats.