{Reference Type}: Journal Article
{Title}: COVID-19 cases and their outcome among patients with uncommon co-existing illnesses: A lesson from Northern India.
{Author}: Reddy DH;Atam V;Rai P;Khan F;Pandey S;Malhotra HS;Gupta KK;Sonkar SK;Verma R; ;
{Journal}: Clin Epidemiol Glob Health
{Volume}: 15
{Issue}: 0
{Year}: 2022 May-Jun
暂无{DOI}: 10.1016/j.cegh.2022.101044
{Abstract}: <B>UNASSIGNED: </B>Newer coexisting conditions should be identified in order to modify newer risk factors. Aim was to identify patients with non-classical or less common coexisting conditions in patients infected of COVID 19.<BR><B>UNASSIGNED: </B>Single centred study from June 2020 to May 2021 at a tertiary centre in North India. A preformed questionnaire was used to record clinical and laboratory parameters and to identify cases which are in addition to CDC list and Indian data.<BR><B>UNASSIGNED: </B>0.67% (46) cases out of 6832 patients were identified to have non-classical coexisting illness. It was divided into 2 groups-infections A (60.1%) and non-infections B (39.9%). Group A included-tuberculosis- pulmonary (14.3%) & extra pulmonary (32.9%), bacterial (25.0%) viral infections [dengue, hepatitis B & C] (14.3%), HIV disease (10.7%) and malaria (3.6%). Group B included- organ transplant (27.8%), autoimmune [myasthenia gravis, polymyositis, psoriasis] (22.6%), haematologic [Haemophilia, ITP, Aplastic anaemia, APML, CML] (27.8%), uncommon malignancies [disseminated sacral chordoma and GTN] (11.1%) and snakebite (11.1%). Serum Procalcitonin was not helpful for diagnosis of bacterial infection in COVID-19 disease. Group A had significantly longer duration of illness, hepatitis and elevated CRP. The mortality in group A & B were 32.1% and 43.8% respectively. Death in non-severe COVID cases was in tetanus and snakebite. 30.7% death among tuberculosis patients. More than 70% of deaths were attributable to COVID 19 in both the groups.<BR><B>UNASSIGNED: </B>In Indian settings, comorbidities like tuberculosis and bacterial infections can precipitate severe COVID 19 unlike other parts of the world where tuberculosis is relatively uncommon.