{Reference Type}: Journal Article
{Title}: Intervention in COVID-19 linked hypercoaguable states characterized by circuit thrombosis utilizing a direct thrombin inhibitor.
{Author}: Seshadri M;Ahamed J;Laurence J;
{Journal}: Thromb Update
{Volume}: 1
{Issue}: 0
{Year}: 2020 Dec
暂无{DOI}: 10.1016/j.tru.2020.100009
{Abstract}: •Circuit thrombosis complicates CRRT in COVID-19 despite standard heparin-based anticoagulation regimens.•5 cases of CRRT thrombosis despite heparin-based anticoagulation resolved using a direct thrombin inhibitor, argatroban.•Changes in fibrinogen levels better reflected response to anticoagulation than did changes in D-dimer levels.•High fibrinogen levels and decreased anti-thrombin III activity may relate to argatroban superiority in these cases.