{Reference Type}: Case Reports
{Title}: Immunotherapy combined with targeted therapy in advanced small cell carcinoma of the ovary of hypercalcemic type: A case of overall survival lasting for over 5 years.
{Author}: Gao Y;Zang L;Ye Y;Ma F;Kang M;Zheng K;Kang Y;Wang H;Xu C;
{Journal}: Eur J Obstet Gynecol Reprod Biol
{Volume}: 297
{Issue}: 0
{Year}: 2024 Jun 6
{Factor}: 2.831
{DOI}: 10.1016/j.ejogrb.2024.04.001
{Abstract}: Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare but highly aggressive ovarian malignant neoplasm lacking a unified clinical management process. Most patients are diagnosed at an advanced stage and have an extremely poor prognosis with an overall probability of survival less than 10 %. Here, we describe the case of a patient with advanced SCCOHT achieved a survival of over 5 years after receiving multiple cycles of immunotherapy combined with anti-angiogenic therapy or CDK4/6 inhibitors. At the same time, we also summarized the case reports and clinical trials of immunotherapy in SCCOHT.