{Reference Type}: Journal Article
{Title}: No causal association between pneumoconiosis and three inflammatory immune diseases: a Mendelian randomization study.
{Author}: Du YJ;Lu ZW;Li KD;Wang YY;Wu H;Huang RG;Jin X;Wang YY;Wang J;Geng AY;Li BZ;
{Journal}: Front Public Health
{Volume}: 12
{Issue}: 0
{Year}: 2024
{Factor}: 6.461
{DOI}: 10.3389/fpubh.2024.1373044
{Abstract}: To investigate the causal relationships between pneumoconiosis and rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and gout.<BR>The random-effects inverse variance weighted (IVW) approach was utilized to explore the causal effects of the instrumental variables (IVs). Sensitivity analyses using the MR-Egger and weighted median (WM) methods were did to investigate horizontal pleiotropy. A leave-one-out analysis was used to avoid the bias resulting from single-nucleotide polymorphisms (SNPs).<BR>There was no causal association between pneumoconiosis and SLE, RA or gout in the European population [OR = 1.01, 95% CI: 0.94-1.10, p = 0.74; OR = 1.00, 95% CI: 0.999-1.000, p = 0.50; OR = 1.00, 95% CI: 1.000-1.001, p = 0.55]. Causal relationships were also not found in pneumoconiosis due to asbestos and other mineral fibers and SLE, RA and gout [OR = 1.01, 95% CI: 0.96-1.07, p = 0.66; OR = 1.00, 95% CI: 1.00-1.00, p = 0.68; OR = 1.00, 95% CI: 1.00-1.00, p = 0.20].<BR>Our study suggests that pneumoconiosis may have no causal relationship with the three inflammatory immune diseases.