{Reference Type}: Journal Article {Title}: Development and Application of the Novel Plant Growth Regulator Guvermectin: A Perspective. {Author}: Liu C;Zhang M;Li L;Wang X;Li S;Xiang W; {Journal}: J Agric Food Chem {Volume}: 72 {Issue}: 15 {Year}: 2024 Apr 17 {Factor}: 5.895 {DOI}: 10.1021/acs.jafc.3c09704 {Abstract}: Plant growth regulators (PGRs) play an important role in alleviating the detrimental effects of biotic and abiotic stress and improving crop yield and quality. As a novel PGR from Streptomyces registered in 2021, guvermectin (GV) has the potential to improve plant yield and defense, making its application in agriculture a subject of interest. Here, we describe the discovery process, functional activities, agricultural applications, toxicity, environmental safety, and biosynthetic mechanism of GV. This Perspective provides a guide for the development of novel PGRs from microorganisms.