{Reference Type}: Journal Article
{Title}: Phenolate-thiazole based reversible "turn-on" chemosensor for the selective detection of carbonate anion: X-ray crystallography, DFT/TDFT, and cell study.
{Author}: Pramanik C;Jana A;Brandao P;Aher A;Bera P;Khatua S;Majumdar S;Mandal B;Kumar Manna S;Bera P;
{Journal}: Spectrochim Acta A Mol Biomol Spectrosc
{Volume}: 315
{Issue}: 0
{Year}: 2024 Jul 5
{Factor}: 4.831
{DOI}: 10.1016/j.saa.2024.124233
{Abstract}: A new phenolate-thiazole derivative (L) has been synthesized and structurally characterized.The chemo-sensing activity of L is detected by the naked eye for the aqueous carbonate anion in the pH range of 4 to 8. The selective 'turn-on' fluorescence occurs through the formation of a stable intermediate L∙CO32-(1) following the PET mechanism. The limit of detection (LOD) is found 0.18 µM based on the absorbance-based assay.The quinonoid form of bromophenol unit binds strongly with CO32- through thiazole nitrogen and hydrazinic nitrogen. Further, the selective holding of CO32- anion over other planar tetranuclear anions (e.g., SO32-, NO3-) happens with several intra and intermolecular hydrogen bonds as envisaged by the DFT/TDFT study. The formation mechanism of L∙CO32- is proposed based on experimental and theoretical studies. The biological experiments (MTT and cell imaging)reveal the non-cytotoxicity nature of L and the biocompatible uptake of L mostly in the cytoplasm at physiological pH.