{Reference Type}: Journal Article
{Title}: Organ involvement in newly diagnosed sarcoidosis patients in the Netherlands: The first large European multicentre prospective study.
{Author}: Van Woensel J;Koopman B;Schiefer M;van Kan C;Janssen MTFH;Ramiro S;Magro-Checa C;Landewé RB;de Kruif MD;Bresser P;Mostard RLM;
{Journal}: Respir Med
{Volume}: 226
{Issue}: 0
{Year}: 2024 May 4
{Factor}: 4.582
{DOI}: 10.1016/j.rmed.2024.107608
{Abstract}: <B>BACKGROUND: </B>Clinical presentation and prevalence of organ involvement is highly variable in sarcoidosis and depends on ethnic, genetic and geographical factors. These data are not extensively studied in a Dutch population.<BR><B>OBJECTIVE: </B>To determine the prevalence of organ involvement and the indication for systemic immunosuppressive therapy in newly diagnosed sarcoidosis patients in the Netherlands.<BR><B>METHODS: </B>Two large Dutch teaching hospitals participated in this prospective cohort study. All adult patients with newly diagnosed sarcoidosis were prospectively included and a standardized work-up was performed. Organ involvement was defined using the WASOG instrument.<BR><B>RESULTS: </B>Between 2015 and 2020, a total of 330 patients were included, 55% were male, mean age was 46 (SD 14) years. Most of them were white (76%). Pulmonary involvement including thoracic lymph node enlargement was present in 316 patients (96%). Pulmonary parenchymal disease was present in 156 patients (47%). Ten patients (3%) had radiological signs of pulmonary fibrosis. Cutaneous sarcoidosis was present in 74 patients (23%). Routine ophthalmological screening revealed uveitis in 29 patients (12%, n = 256)). Cardiac and neurosarcoidosis were diagnosed in respectively five (2%) and six patients (2%). Renal involvement was observed in 11 (3%) patients. Hypercalcaemia and hypercalciuria were observed in 29 (10%) and 48 (26%, n = 182) patients, respectively. Hepatic involvement was found in 6 patients (2%). In 30% of the patients, systemic immunosuppressive treatment was started at diagnosis.<BR><B>CONCLUSIONS: </B>High-risk organ involvement in sarcoidosis is uncommon at diagnosis. Indication for systemic immunosuppressive therapy was present in a minority of patients.