{Reference Type}: Journal Article
{Title}: Bio-Guided Isolation of Alpha-Glucosidase Inhibitory Compounds from Vietnamese Lichen Roccella Montagnei.
{Author}: Thuy Le H;Vu YT;Duong GH;Le TK;Dang MK;Pham DD;Pham NK;Sichaem J;Nguyen NH;Duong TH;
{Journal}: Chem Biodivers
{Volume}: 21
{Issue}: 7
{Year}: 2024 Jul 5
{Factor}: 2.745
{DOI}: 10.1002/cbdv.202400438
{Abstract}: A bio-guided isolation was applied to the Vietnamese lichen Roccella montagnei based on alpha-glucosidase inhibition. Six compounds were isolated and structurally elucidated, including a new ortho depside, montagneside A (1), together with five known compounds, sekikaic acid (2), lanost-7-en-3β-ol (3), ethyl orsellinate (4), D-montagnetol (5), and D-erythrin (6). Their chemical structures were identified by extensive 1D and 2D NMR analysis, high-resolution mass spectroscopy, and comparisons with those reported in the literature. D-Erythrin (6), a major component, was selected for further modification using Smiles rearrangement. Three erythritol derivatives 6a-6c were synthesized. Compounds 1-3, 6, and 6a-6c were evaluated for alpha-glucosidase inhibition. Compounds 2 and 6a-6c showed significant alpha-glucosidase inhibition with IC50 values ranging from 7.9 to 149 μM, respectively. Molecular docking was applied to the most active compound 6a to clarify the inhibitory mechanism.