{Reference Type}: Case Reports
{Title}: Detection of 4p16.3 deletion and 11p15.5p15.4 gain in a boy by comparative genomic hybridization array: A case report.
{Author}: Kaya I;
{Journal}: World J Clin Cases
{Volume}: 12
{Issue}: 8
{Year}: 2024 Mar 16
{Factor}: 1.534
{DOI}: 10.12998/wjcc.v12.i8.1517
{Abstract}: <B>BACKGROUND: </B>Nonallelic homologous recombination (NAHR) of segmental duplications or low copy repeats (LCRs) result in DNA gain/loss and play an important role in the origin of genomic disorders.<BR><B>METHODS: </B>A 3-year- old boy was referred for genetic analysis. Comparative genomic hybridization array analysis revealed a loss of 3776 kb in the 4p16.3 chromosomal region and a gain of 3201 kb in the 11p15.5p15.4 chromosomal region.<BR><B>CONCLUSIONS: </B>Genomic imbalances caused by NAHR in LCRs result in deletion and duplication syndromes.