{Reference Type}: Case Reports {Title}: Fertility Challenges: The Complexities of Retrograde Ejaculation and Cornual Block in Reproductive Health. {Author}: Kasbe MN;More A;Gajabe G;Jadhav R;Bachate P;Mehakar S;Tyagi P; {Journal}: Cureus {Volume}: 16 {Issue}: 3 {Year}: 2024 Mar 暂无{DOI}: 10.7759/cureus.55523 {Abstract}: Infertility, a complicated reproductive health issue that affects both men and women, can have a variety of causes, from anatomical abnormalities to hormone imbalances. This research addresses a couple who have been struggling with infertility for the past four years: a 31-year-old woman with bilateral tubal blockage and her 34-year-old spouse who suffered from primary infertility due to retrograde ejaculation (RE) for the same period. Analyzing the male's semen sample, it was discovered that there were dead sperm and urine, indicating RE. A hysterosalpingography indicated bilateral tubal obstruction in the female partner. Pelvic factors were examined via laparoscopy, which played a crucial role in addressing further issues. The procedure of treatment included testicular sperm aspiration for sperm extraction and intracytoplasmic sperm injection. Hormonal support was involved in the follow-up, and on the 14th day, the β-hCG test came back positive. The intricate procedures of RE and cornual block are discussed, with a focus on how they affect reproductive health.