{Reference Type}: Journal Article
{Title}: Vaso-Lock for sutureless anastomosis in a pig arteriovenous loop model.
{Author}: Li X;Young ER;Martin C;Ribaudo JG;Zaghloul M;Roberts S;Meade R;Arif B;Moritz WR;Madira S;Schofield JB;Xun H;Hicks CW;Kang SH;Zayed MA;Sacks JM;
{Journal}: Biomaterials
{Volume}: 308
{Issue}: 0
{Year}: 2024 Jul 1
{Factor}: 15.304
{DOI}: 10.1016/j.biomaterials.2024.122563
{Abstract}: A vascular anastomosis is a critical surgical skill that involves connecting blood vessels. Traditional handsewn techniques can be challenging and resource intensive. To address these issues, we have developed a unique sutureless anastomotic device called Vaso-Lock. This intraluminal device connects free vascular ends using anchors to maintain traction and enable a rapid anastomosis. We tested the anastomotic capability of Vaso-Locks in a pig common carotid-internal jugular arteriovenous model. The use of Vaso-Lock allowed us to accomplish this procedure in less than 10 min, in contrast to the approximately 40 min required for a handsewn anastomosis. The Vaso-Lock effectively maintained patency for at least 6 weeks without causing significant tissue damage. Histological analysis revealed that the device was successfully incorporated into the arterial wall, promoting a natural healing process. Additionally, organ evaluations indicated no adverse effects from using the Vaso-Lock. Our findings support the safety and effectiveness of the Vaso-Lock for arteriovenous anastomosis in pigs, with potential applicability for translation to humans. Our novel sutureless device has the potential to advance surgical practice and improve patient outcomes.