{Reference Type}: Case Reports
{Title}: Very Long-term Survivorship in Pediatric DIPG: Case Report and Review of the Literature.
{Author}: Dimentberg E;Marceau MP;Lachance A;Bergeron-Gravel S;Saikali S;Crevier L;Bourget C;Hawkins C;Jabado N;Giannakouros P;Renzi S;Larouche V;
{Journal}: J Pediatr Hematol Oncol
{Volume}: 46
{Issue}: 4
{Year}: 2024 05 1
{Factor}: 1.17
{DOI}: 10.1097/MPH.0000000000002853
{Abstract}: Diffuse intrinsic pontine gliomas are lethal tumors with a prognosis generally less than 1 year. Few cases of survivors of 5 years or more have been reported. This case report highlights the journey of a 9.5-year survivor who underwent 3 rounds of focal radiotherapy; she experienced 6 years of progression-free survival following the first round but ultimately succumbed to her disease. An autopsy revealed a favorable IDH1 mutation and the absence of H3K27M. This case reiterates the importance of extensive molecular analyses in diffuse intrinsic pontine gliomas and explores the potential benefit of re-irradiation in patients with positive responses and long periods of remission.