{Reference Type}: Case Reports
{Title}: Pilomatrix carcinoma of the lower extremity: A rare case report and literature review.
{Author}: Ahmed A;Obeid A;Dibas YMS;Bakri IA;Maree M;
{Journal}: Int J Surg Case Rep
{Volume}: 118
{Issue}: 0
{Year}: 2024 May 18
暂无{DOI}: 10.1016/j.ijscr.2024.109528
{Abstract}: <B>BACKGROUND: </B>Pilomatrix carcinoma (PC) is a rare skin malignancy of the hair follicles matrix that tends to be locally aggressive with 10-16 % risk of metastasis mostly to the pulmonary and lymphatic system. There are no clear protocols for the management of PCs, however surgical intervention with clear margins has been highly considered in PC management to decrease risk of recurrence.<BR><B>METHODS: </B>A 40 year-old male patient presented to our clinic to evaluate an asymptomatic, slow-growing nodule localized on his left thigh. A CT scan revealed a well-defined, enhanced lesion with microcalcification. "En bloc" surgical resection of the lesion was performed and histopathology confirmed the diagnosis of pilomatrix carcinoma.<BR><B>UNASSIGNED: </B>Given its rarity, there are no definitive guidelines regarding PC treatment. However, surgical intervention with clear margins including wide local excision or Mohs micrographic surgery has been highly considered. In our case, wide excision of the lesion with clear margins was performed with no evidence of recurrence one year later.<BR><B>CONCLUSIONS: </B>Given the local aggressive nature of PC, appropriate surgical intervention is essential in decreasing the risk of recurrence. Wide excision with clear margins has been proposed to decrease the risk of recurrence. Additionally, total-body skin examination should be done 2-3 times annually to evaluate for recurrence or metastasis.