{Reference Type}: Journal Article
{Title}: Role of FoxO1 in Acne and Effect of Isotretinoin on FoxO1 Expression.
{Author}: Kamboj P;Khullar G;Handa S;Pal A;Saikia UN;De D;
{Journal}: Indian Dermatol Online J
{Volume}: 15
{Issue}: 2
{Year}: 2024 Mar-Apr
暂无{DOI}: 10.4103/idoj.idoj_455_23
{Abstract}: <B>UNASSIGNED: </B>Nodulocystic acne is a severe type of acne that is known to improve after treatment with isotretinoin. Melnik has hypothesized a unifying concept on the mechanism of acne pathogenesis involving altered expression of Forkhead box O transcription factor (FoxO1) and role of isotretinoin in improving acne via modulating this pathway.<BR><B>UNASSIGNED: </B>To evaluate the pathway proposed by Melnik in acne pathogenesis by analysing the difference in the expression of FoxO1, peroxisome proliferator-activated receptor (PPARγ), and androgen receptor (AR) between acne patients and non-acne controls and the effect of treatment with isotretinoin on change in expression of these genes in acne patients.<BR><B>UNASSIGNED: </B>The gene expression of FoxO1 was non significantly higher in acne patients as compared to controls. After treatment with isotretinoin, a significant decrease in FoxO1 expression in acne patients at mRNA (P = 0.05) level was observed. There was a significant decrease in grade 3 positivity of FoxO1 at protein level (P = 0.0009). A decrease in androgen receptor positivity (P = 0.055) at protein level was also observed.<BR><B>UNASSIGNED: </B>Reduction in FoxO1 expression appears to be an important mechanism of action of isotretinoin in acne.