{Reference Type}: Journal Article {Title}: Cracking the NLRP3 code: Pioneering precision medicine for inflammation. {Author}: Weber ANR;Tortola MM;Kuemmerle-Deschner JB; {Journal}: J Exp Med {Volume}: 221 {Issue}: 5 {Year}: 2024 May 6 {Factor}: 17.579 {DOI}: 10.1084/jem.20240221 {Abstract}: Precisely diagnosing and effectively treating cryopyrin-associated periodic syndrome (CAPS), an inflammatory condition linked to gain-of-function NLRP3 inflammasome mutations, poses challenges. A novel classification approach may help inform therapeutic decisions and offer valuable insights into broader inflammatory conditions (Cosson et al. J. Exp. Med. 2024. https://doi.org/10.1084/jem.20231200).