{Reference Type}: Journal Article {Title}: Defense and senescence interplay in legume nodules. {Author}: Berrabah F;Benaceur F;Yin C;Xin D;Magne K;Garmier M;Gruber V;Ratet P; {Journal}: Plant Commun {Volume}: 5 {Issue}: 4 {Year}: 2024 Apr 8 {Factor}: 8.625 {DOI}: 10.1016/j.xplc.2024.100888 {Abstract}: Immunity and senescence play a crucial role in the functioning of the legume symbiotic nodules. The miss-regulation of one of these processes compromises the symbiosis leading to death of the endosymbiont and the arrest of the nodule functioning. The relationship between immunity and senescence has been extensively studied in plant organs where a synergistic response can be observed. However, the interplay between immunity and senescence in the symbiotic organ is poorly discussed in the literature and these phenomena are often mixed up. Recent studies revealed that the cooperation between immunity and senescence is not always observed in the nodule, suggesting complex interactions between these two processes within the symbiotic organ. Here, we discuss recent results on the interplay between immunity and senescence in the nodule and the specificities of this relationship during legume-rhizobium symbiosis.