{Reference Type}: Journal Article
{Title}: Immunocompetent isolated cerebral mucormycosis presenting with obstructive hydrocephalus: illustrative case.
{Author}: Nguyen KN;Freeman LM;Ung TH;Ojemann S;Grassia F;
{Journal}: J Neurosurg Case Lessons
{Volume}: 7
{Issue}: 13
{Year}: 2024 Mar 25
暂无{DOI}: 10.3171/CASE23672
{Abstract}: <B>BACKGROUND: </B>Isolated cerebral mucormycosis is rare in immunocompetent adults and is only sparsely reported to be associated with obstructive hydrocephalus.<BR><B>METHODS: </B>Here, the authors report a case of obstructive hydrocephalus secondary to central nervous system mucormycosis without other systems or rhino-orbital involvement and its technical surgical management. A 23-year-old, incarcerated, immunocompetent patient with history of intravenous (IV) drug use presented with syncope. Although clinical and radiographic findings failed to elucidate an infectious pathology, endoscopy revealed an obstructive mass lesion at the level of the third ventricle, which, on microbiological testing, was confirmed to be Rhizopus fungal ventriculitis. Perioperative cerebrospinal fluid diversion, endoscopic third ventriculostomy, endoscopic biopsy technique, patient outcomes, and the literature are reviewed here. The patient received intrathecal and IV amphotericin B followed by a course of oral antifungal treatment and currently remains in remission.<BR><B>CONCLUSIONS: </B>The patient's unique presentation and diagnosis of isolated cerebral mucormycosis reveal this pathogen as a cause of ventriculitis and obstructive hydrocephalus in immunocompetent adult patients, even in the absence of infectious sequelae on neuroimaging.