{Reference Type}: Journal Article
{Title}: Visit to visit transition in TXNIP gene methylation and the risk of type 2 diabetes mellitus: a nested case-control study.
{Author}: Wu Y;Chen W;Zhao Y;Gu M;Gao Y;Ke Y;Wang L;Wang M;Zhang W;Chen Y;Huo W;Fu X;Li X;Zhang D;Qin P;Hu F;Liu Y;Sun X;Zhang M;Hu D;
{Journal}: J Hum Genet
{Volume}: 69
{Issue}: 7
{Year}: 2024 Jul 25
{Factor}: 3.755
{DOI}: 10.1038/s10038-024-01243-8
{Abstract}: Our study aimed to investigate the association between the transition of the TXNIP gene methylation level and the risk of incident type 2 diabetes mellitus (T2DM). This study included 263 incident cases of T2DM and 263 matched non-T2DM participants. According to the methylation levels of five loci (CpG1-5; chr1:145441102-145442001) on the TXNIP gene, the participants were classified into four transition groups: maintained low, low to high, high to low, and maintained high methylation levels. Compared with individuals whose methylation level of CpG2-5 at the TXNIP gene was maintained low, individuals with maintained high methylation levels showed a 61-87% reduction in T2DM risk (66% for CpG2 [OR: 0.34, 95% CI: 0.14, 0.80]; 77% for CpG3 [OR: 0.23, 95% CI: 0.07, 0.78]; 87% for CpG4 [OR: 0.13, 95% CI: 0.03, 0.56]; and 61% for CpG5 [OR: 0.39, 95% CI: 0.16, 0.92]). Maintained high methylation levels of four loci of the TXNIP gene are associated with a reduction of T2DM incident risk in the current study. Our study suggests that preserving hypermethylation levels of the TXNIP gene may hold promise as a potential preventive measure against the onset of T2DM.