{Reference Type}: Journal Article
{Title}: Tertiary prevention strategies for micrometastatic lymph node cervical cancer: A systematic review and a prototype of an adapted model of care.
{Author}: Śniadecki M;Guani B;Jaworek P;Klasa-Mazurkiewicz D;Mahiou K;Mosakowska K;Buda A;Poniewierza P;Piątek O;Crestani A;Stasiak M;Balaya V;Musielak O;Piłat L;Maliszewska K;Aristei C;Guzik P;Wojtylak S;Liro M;Gaillard T;Kocian R;Gołąbiewska A;Chmielewska Z;Wydra D;
{Journal}: Crit Rev Oncol Hematol
{Volume}: 197
{Issue}: 0
{Year}: 2024 May 26
{Factor}: 6.625
{DOI}: 10.1016/j.critrevonc.2024.104329
{Abstract}: <B>OBJECTIVE: </B>We found a need for balancing the application of clinical guidelines and tailored approaches to follow-up of cervical cancer (CC) patients in the lymph node micrometastatic (MICs) setting. This review aimed to determine the current knowledge of management of MIC-positive CC cases.<BR><B>METHODS: </B>We addressed prognostic and risk of recurrence monitoring impacts associated with MIC+ cases. The electronic databases for literature and relevant articles were analysed.<BR><B>RESULTS: </B>Fifteen studies, (4882 patients), were included in our systematic review. While the results show that MICs significantly worsen prognosis in early CC. A tertiary prevention algorithm for low volume lymph node disease may stratify follow-up according to the burden of nodal disease and provide data that helps improve follow-up performance.<BR><B>CONCLUSIONS: </B>MICs worsen prognosis and should be managed as suggested by the algorithm. However, this algorithm must be externally validated. The clinical impact of isolated tumor cells (ITC) remains unclear.