{Reference Type}: Journal Article
{Title}: Biomechanical analysis of the human derived soft tissue graft Epiflex for use in oral soft tissue augmentation.
{Author}: Sagheb K;Noelken R;Schröger SV;Walter C;Graef JJ;Schumann S;
{Journal}: Int J Implant Dent
{Volume}: 10
{Issue}: 1
{Year}: 2024 Mar 22
{Factor}: 2.984
{DOI}: 10.1186/s40729-024-00534-1
{Abstract}: <B>OBJECTIVE: </B>This study aimed to investigate the biomechanical properties, cell migration, and revascularization of the acellular dermal matrix Epiflex. As a decellularized, freeze-dried human skin graft, Epiflex has broad applications in medical fields, particularly in implantology and dentistry. Understanding its biomechanical characteristics is crucial for its clinical adoption as a novel soft tissue graft option.<BR><B>METHODS: </B>Epiflex (n = 3) was evaluated in comparison to palatal tissue from body donors (n = 3). Key metrics, such as elongation and tear resistance, were quantified. Both graft types underwent histological analysis and scanning electron microscopy. Additionally, the healing properties of Epiflex were assessed using a Chorioallantoic Membrane (CAM) Assay.<BR><B>RESULTS: </B>Biomechanically, Epiflex (mean = 116.01 N) demonstrated the ability to withstand greater forces (p = 0.013) than human palatal tissue (mean = 12.58 N). When comparing the elongation, no significant difference was measured (ASG mean = 9.93 mm, EF mean = 9.7 mm). Histologically, Epiflex exhibited a loosely connected network of collagen fibers with a dense upper layer. The CAM Assay indicated efficient revascularization.<BR><B>CONCLUSIONS: </B>Epiflex appears to be a viable option for soft tissue augmentation, particularly appealing to patient groups who avoid all or specific animal-derived products due to ethical or religious reasons.