{Reference Type}: Journal Article
{Title}: Purinergic Receptor P2Y12-Mediated Tau Internalization in Microglia.
{Author}: Chidambaram H;Desale SE;Chinnathambi S;
{Journal}: Methods Mol Biol
{Volume}: 2754
{Issue}: 0
{Year}: 2024
暂无{DOI}: 10.1007/978-1-0716-3629-9_25
{Abstract}: Microglia are the resident brain macrophage cells that are involved in constant surveillance of brain microenvironment. In Alzheimer's disease, microglia get over activated upon the accumulation of Tau and amyloid-β species in the extracellular space, ultimately leading to neurodegeneration. Microglia phagocytose the extracellular Tau species by several mechanisms among which P2Y12 receptor-mediated internalization of extracellular Tau is recently studied. Extracellular Tau activates microglia and directly interacts with the P2Y12 receptor. Tau-receptor complex is then internalized followed by perinuclear accumulation and lysosomal degradation. Upon microglial activation by extracellular Tau, P2Y12 receptor is also involved in membrane-associated actin remodeling which has its key role in active migration and phagocytosis.