{Reference Type}: Journal Article
{Title}: The diagnostic performance of ultrafast MRI to differentiate benign from malignant breast lesions: a systematic review and meta-analysis.
{Author}: Amitai Y;Freitas VAR;Golan O;Kessner R;Shalmon T;Neeman R;Mauda-Havakuk M;Mercer D;Sklair-Levy M;Menes TS;
{Journal}: Eur Radiol
{Volume}: 0
{Issue}: 0
{Year}: 2024 Mar 21
{Factor}: 7.034
{DOI}: 10.1007/s00330-024-10690-y
{Abstract}: <B>OBJECTIVE: </B>To assess the diagnostic performance of ultrafast magnetic resonance imaging (UF-DCE MRI) in differentiating benign from malignant breast lesions.<BR><B>METHODS: </B>A comprehensive search was conducted until September 1, 2023, in Medline, Embase, and Cochrane databases. Clinical studies evaluating the diagnostic performance of UF-DCE MRI in breast lesion stratification were screened and included in the meta-analysis. Pooled summary estimates for sensitivity, specificity, diagnostic odds ratio (DOR), and hierarchic summary operating characteristics (SROC) curves were pooled under the random-effects model. Publication bias and heterogeneity between studies were calculated.<BR><B>RESULTS: </B>A final set of 16 studies analyzing 2090 lesions met the inclusion criteria and were incorporated into the meta-analysis. Using UF-DCE MRI kinetic parameters, the pooled sensitivity, specificity, DOR, and area under the curve (AUC) for differentiating benign from malignant breast lesions were 83% (95% CI 79-88%), 77% (95% CI 72-83%), 18.9 (95% CI 13.7-26.2), and 0.876 (95% CI 0.83-0.887), respectively. We found no significant difference in diagnostic accuracy between the two main UF-DCE MRI kinetic parameters, maximum slope (MS) and time to enhancement (TTE). DOR and SROC exhibited low heterogeneity across the included studies. No evidence of publication bias was identified (p = 0.585).<BR><B>CONCLUSIONS: </B>UF-DCE MRI as a stand-alone technique has high accuracy in discriminating benign from malignant breast lesions.<BR><B>CONCLUSIONS: </B>UF-DCE MRI has the potential to obtain kinetic information and stratify breast lesions accurately while decreasing scan times, which may offer significant benefit to patients.<BR><B>CONCLUSIONS: </B>• Ultrafast breast MRI is a novel technique which captures kinetic information with very high temporal resolution. • The kinetic parameters of ultrafast breast MRI demonstrate a high level of accuracy in distinguishing between benign and malignant breast lesions. • There is no significant difference in accuracy between maximum slope and time to enhancement kinetic parameters.