{Reference Type}: Journal Article
{Title}: Pyroptotic T cell-derived active IL-16 has a driving function in ovarian endometriosis development.
{Author}: Zhang J;Zhao W;Zhou Y;Xi S;Xu X;Du X;Zheng X;Hu W;Sun R;Tian Z;Fu B;Wei H;
{Journal}: Cell Rep Med
{Volume}: 5
{Issue}: 3
{Year}: 2024 Mar 19
{Factor}: 16.988
{DOI}: 10.1016/j.xcrm.2024.101476
{Abstract}: Endometriosis, affecting 6%-10% of women, often leads to pain and infertility and its underlying inflammatory mechanisms are poorly understood. We established endometriosis models in wild-type and IL16KO mice, revealing the driver function of IL-16 in initiating endometriosis-related inflammation. Using an in vitro system, we confirmed iron overload-induced GSDME-mediated pyroptosis as a key trigger for IL-16 activation and release. In addition, our research led to the development of Z30702029, a compound inhibiting GSDME-NTD-mediated pyroptosis, which shows promise as a therapeutic intervention for endometriosis. Importantly, our findings extend beyond endometriosis, highlighting GSDME-mediated pyroptosis as a broader pathway for IL-16 release and offering insights into potential treatments for various inflammatory conditions.